Sensitive Voltammetric Determination of Acetaminophen at Poly(4-vinyl pyridine)/Graphene Composite Modified Electrode

Document Type : Research Paper

Authors

1 Department of Chemistry, Yadegar Imam Khomeini (RAH), Islamic Azad University

2 Department of Chemistry, Faculty of Science, University of Malaya, 50603 KualaLumpur, Malaysia. Department of Chemistry, The University of Akron, Akron, OH 44325-3601, USA

Abstract

This study demonstrates the use of a selective and sensitive voltammetric sensor for determination of acetaminophen (AC). This was  performed by modifying a glassy carbon electrode with composite film of poly(4-vinylpyridine) and graphene sheet (P4VP/GR-GCE). The redox peak currents of AC increased significantly at P4VP/GR-GCE. The result was achieved by the synergistic effect of combined electron mediator property of P4VP along with remarkable physical properties of GR which improved the kinetics of the catalytic oxidation of AC. The P4VP/GR-GCE exhibited excellent sensitivity, good reproducibilityand long-termstability for measuring AC with detection limits of 3.2 nM in the linear range of 0.04-300 µM. The novel developed sensor was not interfered by physiologically common interference, viz. ascorbic acid (AA) and uric acid (UA). The P4VP/GR-GCE was also successfully applied for detection of AC in tablets and urine samples, so it is reasonable to expect its broad use as AC sensor.

Keywords

References

[1]       H. Yin, Q. Ma, Y. Zhou, S. AiL. Zhu, Electrochim. Acta 55 (2010)7102.
 [2]        T.-L. Lu, Y. C. Tsai, Sens. Actuators B: Chem. 153 (2011)439.
 [3]        A. Kratz, M. Ferraro, P. M. Sluss, K. B. Lewandrowski, New Engl. J. Med. 351 (2004)1548.
[4]        M.-P. N. Bui, C. A. Li, K. N. Han, X.-H. Pham, G. H. Seong, Sens. Actuators B:  Chem. 174 (2012)318.
[5]        M. Mazer, J. Perrone, J. Med. Toxicol. 4 (2008)2.
 [6]        Sirajuddin, A. R. Khaskheli, A. Shah, M. I. Bhanger, A. Niaz, S. Mahesar, Spectrochim. Acta, Part A 68(2007) 747.
 [7]        C. Nebot, S. W. Gibb, K. G. Boyd, Anal. Chim. Acta598 (2007)87.
 [8]        M. K. Srivastava, S. Ahmad, D. SinghI, C. Shukla, Analyst 110 (1985)735.
 [9]        D. Easwaramoorthy, Y.-C. Yu, H. J. Huang, Anal. Chim. Acta 439 (2001)95.
 [10]      M.-E. Capella-Peiró, D. Bose, M. F. Rubert, J. Esteve-Romero, J. Chromatogr. B 839 (2006)95.
 [11]      M. Knochen, J. Giglio, B. F. Reis, J. Pharm. Biomed. Anal. 33 (2003)191.
[12]      F.G.Delolo, C.Rodrigues, M.M.Silva,L. R.Dinelli,F. N.Delling,J. Z.Schpectorc,
            A. A.Batista, J. Braz. Chem. Soc. 25(2014) 550.
 [13]      D. Nematollahi, H. Shayani-Jam, M. Alimoradi, S. Niroomand, Electrochim. Acta 54 (2009)7407.
 [14]     H. Ghadimi, B. N. Tabrizi, P. Moozarm Nia, W. J. Basirun, R. M. A.Tehrani, F.
            Lorestani,RSC Adv. 5 (2015) 99555.
 [15]     W. J. Basirun, M. Sookhakian, S. Baradaran, Z. Endut, M. R. Mahmoudian, M. Ebadi,
            R. Yousefi, H. Ghadimi, S. Ahmed, Sci. Rep. 5 (2015) 9108. 
 [16]      C.-X. Xu, K.-J. Huang, Y. Fan, Z.-W. Wu, J. Li, J. Mol. Liq. 165 (2012) 32.
 [17]      F. Kim, L. J. Cote, J. Huang, Adv. Mater. 22 (2010) 1954.
 [18]      Z. Tang, H. Wu, J. R. Cort, G. W. Buchko, Y. Zhang, Y. Shao, I. A. Aksay, J. Liu, Y. Lin, Small 6 (2010) 1205.
 [19]      A. Kaniyoor, S. Ramaprabhu, J. Mater. Chem. 22 (2012) 8377.
[20]      Z. Liu, Z. Wang, Y. Cao, Y. Jing, Y. Liu, Sens. Actuators B: Chem. 157 (2011) 540.
 [21]      Y. Fan, J.-H. Liu, C.-P. Yang, M. Yu, P. Liu, Sens. Actuators B:  Chem. 157 (2011)669.
 [22]      Z. Zhuang, J. Li, R. Xu, D. Xiao, Int. J. Electrochem. Sci. 6 (2011) 2149.
 [23]      Z. Y. Zeng, S. L. Gupta, H. Huang, E. B. Yeager, J. Appl. Electrochem. 21 (1991) 973.
 [24]      J. Wang, T. Golden, T. Peng, Anal. Chem. 59 (1987) 740.
[25]      J. Li, J. D. Qiu, J. J. Xu, H. Y. Chen, X. H. Xia, Adv. Funct. Mater. 17 (2007) 1574.
 [26]      R. Verdejo, M. M. Bernal, L. J. Romasanta, M. A. Lopez-Manchado, J. Mater.Chem. 21(2011)3301.
 [27]     S. Cheemalapati, S. Palanisamy, V. Mani, S. M. Chenn, Talanta 117 (2013) 297.
 [28]     H. Ghadimi, R. M.A. Tehrani, A. S. Mohamed Ali, N. Mohamed, S. Ab Ghani,Anal.
            Chim. Acta 765 (2013) 70.
 [29]     R. M.A. Tehrani, H. Ghadimi, S. Ab Ghani, Sens. Actuators B: Chem. 177 (2013)
            612.
 [30]     A. Mao, H. Li, D. Jin, L. Yu, X. Hu, Talanta144 (2015)252.
 [31]      J.M. Hui, W.J. Li, Y.L. Guo, Z. Yang, Y.X. Wang, C. Yu, Biosyst. Eng. 37 (2014) 461.
 [32]      F. Ghorbani-Bidkorbeh, S. Shahrokhian, A. Mohammadi, R. Dinarvand, Electrochim. Acta 55 (2010) 2752.
 [33]      B. Habibi, M. Jahanbakhshi, M. H. Pournaghi-Azar, Anal. Biochem. 411 (2011) 167.
 [34]      S. A. Kumar, C.-F. Tang, S.-M. Chen, Talanta76 (2008) 997.
 [35]      M. D. P. T. Sotomayor, A. Sigoli, M. R. V. Lanza, A. A. Tanaka, L. T. Kubota, J. Braz. Chem. Soc. 19 (2008)734.
 [36]      M. M. Ardakani, S. H. Ahmadi,Z. S. Mahmoudabadi,A. Khoshroo, J. Braz. Chem. Soc. 25 (2014) 1630.
 [37]      X. Kang, J. Wang, H. Wu, J. Liu, I. A. Aksay, Y. Lin, Talanta 81 (2010) 754.
 [38]      M. Li, L. Jing, Electrochim. Acta 52 (2007) 3250.
 [39]      M. Zidan, T. W. Tee, A. H. Abdullah, Z. Zainal, G. J. Kheng, Int. J. Electrochem. Sci. 6 (2011) 279.
 [40]      G. Sánchez-Obrero, M. Mayén, J. M. R. Mellado, R. Rodríguez-Amaro, Int. J. Electrochem. Sci. 6 (2001) 2001.
 [41]      Q. Wan, X. Wang, F. Yu, X. Wang, N. Yang, J. Appl. Electrochem.39 (2009) 785.
 [42]      I. Noviandri, R. Rakhmana, Int. J. Electrochem. Sci.7 (2012) 4479.
 [43]      W. Zhu, H. Huang, X. Gao, H. Ma, Mater. Sci. Eng. C 45 (2014) 21.
 [44]      M. Amiri-Aref, J. B. Raoof, R. Ojani, Sens. Actuators B: Chem. 192 (2014) 634.
[45]      L. Ahmadpour-Mobarakeh, A. Nezamzadeh-Ejhieh, Ma, Mater. Sci. Eng. C 49(2015)
493.
 [46]     Y. E. Bouabi, A. Farahi, N. Labjar, S. E. Hajjaji, M. Bakasse, M.A. E. Mhammedi,
            Mater. Sci. Eng. C 58 (2016) 70.
 [47]      B. J. Sanghavi, A. K. Srivastava, Electrochim.Acta 55 (2010) 8638.

Files

Share

How to cite

Statistics