@article { author = {Farajian, Fereshteh and Hashemi, Payman}, title = {Silica-Coated Magnetic Tragacanth Gum Nanoparticles Crosslinked with Citric Acid for the Loading and Delivery of Ranitidine}, journal = {Analytical and Bioanalytical Chemistry Research}, volume = {10}, number = {1}, pages = {111-120}, year = {2023}, publisher = {Iranian Chemical Society}, issn = {2383-093X}, eissn = {2383-093X}, doi = {10.22036/abcr.2022.347479.1785}, abstract = {A new magnetic nanocomposite was prepared by synthesizing Fe3O4@SiO2 nanoparticles and then coating them with a shell of tragacanth gum (TG) as a natural product modified by citric acid (CA). The obtained Fe3O4@SiO2@TG@CA nanoparticles were identified by scanning electron microscopy (SEM), energy dispersive X-ray analysis (EDX) and Fourier transform infrared spectroscopy (FT-IR). The prepared magnetic nanoparticles were used for loading and delivery of ranitidine, an oral drug. Conditions for drug loading were optimized by a central composite design optimization method. The maximum loading efficiency for ranitidine was 79.3% that was obtained at pH 11 and its in vitro release was gained within 55 min at pH 1.6 in a phosphate buffer medium. The loading capacity of the nanocarrier was dependent on the initial concentration of ranitidine and exceeded 11.4 mg g-1 in a solution of 200 mg L-1. The study of adsorption isotherms to describe the interaction of ranitidine with the carrier showed the best fit with Freundlich isotherm. The results showed that the prepared Fe3O4@SiO2@TG@CA adsorbent, as a non-toxic and low-cost nanocarrier, is quite suitable for drug delivery applications.}, keywords = {Magnetic nanoparticles,Tragacanth Gum,Citric acid,Drug Delivery,Hydrogel}, url = {https://www.analchemres.org/article_160622.html}, eprint = {https://www.analchemres.org/article_160622_4f1dc0b0a2ebd6a75006a83da4408be8.pdf} }