@article { author = {Baezzat, Mohammad Reza and Banavand, Fatemeh and Kamran Hakkani, Sedigheh}, title = {Sensitive Voltammetric Detection of Indomethacin Using TiO2 Nanoparticle Modified Carbon Ionic Liquid Electrode}, journal = {Analytical and Bioanalytical Chemistry Research}, volume = {7}, number = {1}, pages = {89-98}, year = {2020}, publisher = {Iranian Chemical Society}, issn = {2383-093X}, eissn = {2383-093X}, doi = {10.22036/abcr.2019.171887.1317}, abstract = {In this work, a TiO2 nanoparticle modified carbon ionic liquid electrode (CILE) was employed as a sensitive sensor for the investigation of the electrochemical behavior of indomethacin (IND). This nanocomposite sensor has been fabricated by incorporation of TiO2 nanoparticles and the ionic liquid 1-hexylpyridinium hexafluorophosphate (HPFP). The surface of the electrode was studied by scanning electron microscopy (SEM). Differential pulse voltammetry (DPV) was used for quantification of sub-micromolar amounts of IND. Electrochemical parameters of the electrode reaction of IND, including the electron transfer coefficient (α) and the electron-transfer number (n), were calculated by cyclic voltammetry (CV) methods. Under selected conditions, the anodic peak current was linear for the concentration of IND in the broad range of 1.0 × 10-7 to 1.0 × 10-4 M with the detection limit of 2.1× 10-8 M. Moreover, the analytical performance of the proposed method for the determination of IND content in plasma samples was evaluated with good sensitivity and acceptable recoveries.}, keywords = {Carbon ionic liquid electrode,indomethacin,TiO2 nanoparticle,Voltammetry}, url = {https://www.analchemres.org/article_91757.html}, eprint = {https://www.analchemres.org/article_91757_baa0f763f03efc9005109b60f7d2b75b.pdf} }