%0 Journal Article %T Ni2+ Ion Sensing by a Semicarbazone Derivative of Piperidin-4-one: A Spectrofluorimetric Study %J Analytical and Bioanalytical Chemistry Research %I Iranian Chemical Society %Z 2383-093X %A Sumathi, P %A Kiruthiga, K %A Ramasamy, Sivaraj %A Selvakumar, P Mosae %A Enoch, Israel VMV %D 2022 %\ 07/01/2022 %V 9 %N 3 %P 235-241 %! Ni2+ Ion Sensing by a Semicarbazone Derivative of Piperidin-4-one: A Spectrofluorimetric Study %K Semicarbazone %K Piperidone %K Ni2+ sensing %K Fluorescent chemosensor %K β-Cyclodextrin %K Host-guest complex %R 10.22036/abcr.2021.182833.1337 %X Nickel ions are toxic to the environment and they are also relevant in biology. Fluorescence sensing is a sensitive method and metal sensing can be carried out employing cheaper and easy-to-synthesize molecules that possess fluorescence emission. Therefore, development of newer and simply-synthesized chemosensor molecules for nickel ions in aqueous medium are required. We report, in this paper, a simple semicarbazone derivative of a piperidin-4-one as a nickel ion sensor in water. The compound forms a 1:1 stoichiometric complex with nickel ions. The association constant value is 4.04 × 104 mol-1 dm3. The nickel ion-selectivity of the compound is explored emploting UV-vis and fluorescence spectroscopy. Ni2+ ion-chelation enhances the fluorescence of the chemosensor molecule. The Ni2+ detection limit of the chemosensor was 1 × 10-7 mol dm-3. The compound also forms a 1:2 inclusion complex with β-cyclodextrin. The structure of the complex is proposed. Host : guest complex formation of β-cyclodextrin with the piperidin-4-one derivative results in the interference of the host molecule with the chelation of Ni2+ ions. As an extension of the application of the piperidin-4-one derivative, we demonstrate the Ni(II) ion filtration by incorporating the compound with a polysulfone film. %U https://www.analchemres.org/article_143233_6f71e7a306539bec3e92a259d312e468.pdf