TY - JOUR ID - 163004 TI - Modification of Multi-walled Carbon Nanotubes Composite Paste Electrode with Nanonickel Pentacyanonitrosylferrate and Nickel Oxide Nanoparticles for Non-enzymatic Glucose Determination JO - Analytical and Bioanalytical Chemistry Research JA - ABCR LA - en SN - AU - Hasanzadeh, Mahsa AU - Sayadi, Mehran AU - Alizadeh, Sakineh AU - Ghasemlu, Khosrow AD - Department of Food Safety and Hygiene, School of Health, Fasa University of Medical Sciences, Fasa, Iran. Department of Food and Drug Laboratory, Food and Drug Administration, Urmia University of Medical Sciences, Urmia, Iran AD - Department of Food Safety and Hygiene, School of Health, Fasa University of Medical Sciences, Fasa, Iran AD - Faculty of Chemistry, Bu-Ali Sina University, Hamadan, Iran AD - Department of Food and Drug Laboratory, Food and Drug Administration, Urmia University of Medical Sciences, Urmia, Iran Y1 - 2023 PY - 2023 VL - 10 IS - 2 SP - 183 EP - 192 KW - Nickel pentacyanonitrosylferrate KW - MWCNTs KW - Nickel Oxide KW - Glucose KW - electrochemical KW - Sensor DO - 10.22036/abcr.2022.359945.1820 N2 - A novel non-enzymatic electrochemical sensor with high sensitivity for glucose determination was introduced herein with nickel pentacyanonitrosylferrate (NiPCNF)-modified multi-walled carbon nanotubes (MWCNTs) paste electrode and deposited nickel hydroxide onto paste electrode using NiSO4 solution and H2SO4 as the soft template. The NiO-modified electrode was scanned with cyclic voltammetry (CV) method in alkaline media to obtain Ni(OH)2/NiOOH particles as glucose electrocatalyst. The prepared nickel oxide was then mixed with the paste inside the tube. It was observed that introducing both NiPCNF and NiO could synergistically improve the activity toward electrocatalytic oxidation of glucose with an increase in the accessible active sites and promotion of the electron transport capability. Therefore, the modified electrode did not only exhibit an outstanding electrochemical behavior but also decreased the potential for electrochemical oxidation and enhanced the affinity of the electrode to glucose. Field emission scanning electron microscopy (FESEM) was applied to study the surface morphology of the electrode and prepared NiPCNF powder. After optimizing the condition, the chronoamperometry (CA) technique was applied for glucose determination. Porous-modified electrode, containing both nanomaterials of NiPCNF and NiO, exhibited a vast linear range from 5 µM to 1.95 mM (2.6 orders of magnitude) with a low limit of detection (LOD) of 2.35 × 10-7 ± 1.52×10-8 M (S/N=3) and high sensitivity (2.83 ± 0.17 mA mM-1 cm-2). Finally, the prepared sensor was utilized for glucose determination in the real samples successfully. UR - https://www.analchemres.org/article_163004.html L1 - https://www.analchemres.org/article_163004_1c5d481fa3e5809bdad7146a592299e4.pdf ER -