TY - JOUR ID - 61770 TI - The Spectrophotometric Determination of Nystatin in Real Samples Using Solid Phase Extraction Based on Sodium Dodecyl Sulphate-Coated Magnetite Nanoparticles JO - Analytical and Bioanalytical Chemistry Research JA - ABCR LA - en SN - AU - Rahimi Fard, Marjan AU - Pourghobadi, Zeinab AD - Department of Chemistry, Khorramabad Branch, Islamic Azad University, Khorramabad, Iran Y1 - 2018 PY - 2018 VL - 5 IS - 2 SP - 249 EP - 259 KW - Nystatin KW - Magnetic solid-phase extraction KW - Sodium dodecyl sulfate KW - Magnetic nanoparticle DO - 10.22036/abcr.2018.102515.1170 N2 - The purpose of this study was to separate and determine Nystatin in water, urine and plasma samples using a method based on sodium dodecyl sulfate (SDS) coated magnetic nanoparticles (nano-magnets Fe3O4) along with spectrophotometry which has been developed for to this end. Due to their excellent adsorption capacity and high chemical stability, nanoparticles can be modified by surfactants. The extraction efficiency of Nystatin can be affected by different factors such as the amount of adsorbent, pH value, eluent type and its volume, extraction time, and ionic strength; these factors have been further studied and optimized. The method was successfully employed for extracting Nystatin from water, urine and plasma samples under optimized condition. The linear response of the method was over ranges of 1-20, 1–18 and 1–15 mg/L and the coefficients of determination were 0.991, 0.994 and 0.991; these desirable coefficients were achieved for of water, urine and plasma samples, respectively. In addition, it was tried to investigate the relative recovery in different water, urine and plasma matrices and subsequently the values of 99%, 98% and 102% were obtained. It could be concluded that the method employed here was conveniently fast, linear, efficient and economical for extracting Nystatin in water and biological samples. UR - https://www.analchemres.org/article_61770.html L1 - https://www.analchemres.org/article_61770_9764f485292f0ac68e5d2a4f9242f61a.pdf ER -