Solid Phase Extraction of Letrozole by a Metal Organic Framework and its HPLC-UV Characterization

Document Type : Research Paper

Authors

1 Nano Drug Delivery Research Center, Health Technollogy Institute, Kermanshah University of Medical Sciences, Kermanshah, Iran

2 Department of Chemistry, Tarbiat Modares University, P. O. Box: 14115-175, Tehran, Iran

10.22036/abcr.2021.245300.1534

Abstract

We successfully synthesized TMU-24 as metal-organic framework (MOF) and employed as an effective sorbent for preconcentration of the letrozole (LTZ) from biological samples. Using high-performance liquid chromatography with UV detector (HPLC-UV) coupling with solid-phase extraction (SPE) a sensitive, fast, and simple method for deteing of LTZ has been developed. The optimal conditions, such as pH, type of eluent solvents, contact time amount of adsorbent, and adsorption capacity were discussed. Under the optimized conditions, relative recoveries (RR) and preconcentration factor (PF) of the LTZ was obtained in the range of 92.4–99.6% and 33 respectively. Under the optimal conditions, LTZ can be determined with a limits of detection (LODs) 0.5 μg L-1 (based on S/N = 3), a linearity in the range of 1–250 μg L-1, and a reasonable linearity of 0.995. Also, the experimental adsorption isotherms models were investigated. The developed method was successfully used to the analysis of LTZ in urine samples.

Keywords


[1]           S.P. Hooshyar, R.Z. Mehrabian, H.A. Panahi, M.H. Jouybari, H. Jalilian, Colloid Surface B: Biointerfaces 176 (2019) 404.
[2]           E.M. Zwiefelhofer, B.M. Davis, G.P. Adams, Theriogenology 146 (2020) 104.
[3]           S. Padash Hooshyar, R.Z. Mehrabian, H. Ahmad Panahi, M. Habibi Jouybari, H. Jalilian, Microchem. J. 143 (2018) 190.
[4]           A.I. Platova, I.I. Miroshnichenko, S.N.  Ptitsina,  N.I.
 
 
Yurchenko, Pharmaceut. Chem. J. 48 (2014) 292.
[5]           J.C. Precht, B. Ganchev, G. Heinkele, H. Brauch, M. Schwab, T.E. Mürdter, Anal. Bioanal. Chem. 403 (2012) 301.
[6]           B.B. Chavan, S. Tiwari, S.G., R.D. Nimbalkar, P. Garg, S.R. M.V.N.K. Talluri, J. Pharmaceut. Biomed. Anal. 157 (2018) 59.
[7]           P.G. Vanol, P. Singhal, P.A. Shah, J.V. Shah, P.S. Shrivastav, M. Sanyal, J. Pharmaceut. Anal. 6 (2016) 276.
[8]           J. Rodríguez Flores, A.M.C. Salcedo, M.J.V. Llerena, L.M. Fernández, J. Chromatogr. A 1185 (2008) 281.
[9]           E. Gerace, A. Salomone, G. Abbadessa, S. Racca, M. Vincenti, J. Pharmaceut. Anal. 2 (2012) 1.
[10]        M. Locatelli, N. Tinari, A. Grassadonia, A. Tartaglia, D. Macerola, S. Piccolantonio, E. Sperandio, C. D'Ovidio, S. Carradori, H.I. Ulusoy, K.G. Furton, A. Kabir, J. Chromatogr. B 1095 (2018) 204.
[11]        J. Rodríguez, G. Castañeda, L. Muñoz, J. Chromatogr. B 913-914 (2013) 12.
[12]        X. Xiong, Y. Zhang, Anal. Bioanal. Chem. 412 (2020) 2763.
[13]        M. Hazrati, M. Safari, Environmental Progress & Sustainable Energy 39 (2020) 13411.
[14]        J. Xiao, J. Wang, H. Fan, Q. Zhou, X. Liu, Int. J. Environ. Anal. Chem. 96 (2016) 407.
[15]        F. Salimi, M. Shamsipur, E. Koosha, M. Ramezani, Int. J. Environ. Anal. Chem. 100 (2020) 1.
[16]        Z. Tekin, N. Özdoğan, S. Bakırdere, Int. J. Environ. Anal. Chem.  100 (2020) 1.
[17]        N. Ebrar Karlidag, E. Seda Kocoglu, M. Toprak, O. Yilmaz, S. Bakirdere, Food Chem. 329 (2020) 127210.
[18]        I. Vasconcelos, P.H.R. da Silva, D.R.D. Dias, M.B. de Freitas Marques, W. da Nova Mussel, T.A. Pedrosa, M.E.S. Ribeiro e Silva, R.F. de Souza Freitas, R.G. de Sousa, C. Fernandes, Mater. Sci. Engin.: C 116 (2020) 111191.
[19]        K.O. Sulaiman, M. Sajid, K. Alhooshani, Microchem. J. 152 (2020) 104289.
[20]        M. Wójciak-Kosior, I. Sowa, S. Dresler, J. Kováčik, M. Staniak, J. Sawicki, S. Zielińska, R. Świeboda, M. Strzemski, R. Kocjan, Talanta 194 (2019) 32.
 
 
[21]        E. Milanetti, G. Carlucci, P.P. Olimpieri, P. Palumbo, M. Carlucci, V. Ferrone, J. Chromatogr. A 1605 (2019) 360351.
[22]        K. Hroboňová, A. Machyňáková, J. Čižmárik, J. Chromatogr. A 1539 (2018) 93.
[23]        M. Manouchehri, S. Seidi, A. Rouhollahi, H. Noormohammadi, M. Shanehsaz, Food Chem. 314 (2020) 126223.
[24]        Y. Yamini, M. Safari, Microchem. J. 146 (2019) 134.
[25]        M. Safari, Y. Yamini, M.Y. Masoomi, A. Morsali,    A. Mani-Varnosfaderani, Microchimica Acta 184 (2017) 1555.
[26]        H. Ehzari, M. Amiri, M. Safari, Talanta 210 (2020) 120641.
[27]        M. Shakourian, Y. Yamini, M. Safari, Talanta 218 (2020) 121139.
[28]        Y. Yamini, M. Safari, A. Morsali, V. Safarifard, J. Chromatogr. A 1570 (2018) 38.
[29]        M. Safari, M. Shahlaei, Y. Yamini, M. Shakorian, E. Arkan, Anal. Chim. Acta 1034 (2018) 204.
[30]        N.  Abdollahi,  S.A. Akbar Razavi, A. Morsali, M.-L.
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
Hu, J. Hazard. Mater. 387 (2019) 121667.
[31]        M. Safari, Y. Yamini, A. Mani-Varnosfaderani, H. Asiabi, J. Iran. Chem. Soc. 14 (2017) 623.
[32]        F. Golmohammadi, M. Hazrati, M. Safari, Microchem. J. 144 (2019) 64.
[33]        M. Bashir, S. Tyagi, A.P. Annachhatre, Materials Today: Proceedings 28 (2020) 1833.
[34]        S. Padash Hooshyar, R. Zafar Mehrabian, H. Ahmad Panahi, M. Habibi Jouybari, H. Jalilian, Microchem. J. 143 (2018) 190.
[35]        M. Rezaee, Y. Yamini, M. Hojjati, M. Faraji, Anal. Methods 2 (2010) 1341.
[36]        M.K. Mohammadi Nodeh, M. Rahemi Haghighi,             S. Soltani, H. Rashidi Nodeh, J. Liq. Chromatogr. Relat. Technol. 41 (2018) 239.
[37]        J. Rodríguez-Flores, A.M. Contento Salcedo, L.M. Fernández, Electrophoresis 30 (2009) 624.
[38]        A. Nazaripour, Y. Yamini, H. Bagheri, J. Sep. Sci. 41 (2018) 3113.
[39]        Y. Dange, S. Bhinge, V. Salunkhe, Toxicol. Mech. Methods 28 (2018) 187.