Electroanalytical Determination of Gemifloxacin Mesylate in Bulk, Tablets and Human Urine Using Gold Nanoparticles Modified Carbon Paste Electrode

Attia, Ali Kamal; Abd-Elmoety, Mona; Badawy, Amr M; Abd-Elaleem, Abd-Elazis; Abd-Elhamid, Samar G

doi:10.22036/abcr.2014.7527

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	Electroanalytical Determination of Gemifloxacin Mesylate in Bulk, Tablets and Human Urine Using Gold Nanoparticles Modified Carbon Paste Electrode
Article 6, Volume 1, Issue 2, Summer and Autumn 2014, Page 128-138 PDF (1.15 MB)
Document Type: Research Paper
DOI: 10.22036/abcr.2014.7527
Authors
Ali Kamal Attia ¹; Mona Abd-Elmoety²; Amr M Badawy³; Abd-Elazis Abd-Elaleem³; Samar G Abd-Elhamid²
¹National Organization for Drug Control and Research (NODCAR)
²National Organization for Drug Control and Research
³Analytical Chemistry Department, Faculty of Pharmacy, Cairo University
Abstract
A simple, precise, inexpensive and sensitive voltammetric method has been developed for the determination of gemifloxacin mesylate (GEM) in the presence of tween 80 in the bulk, farmaceutical dosage forms and human urine at gold nanoparticles modified carbon paste electrode (GNCPE). The electrochemical behavior of GEM has been investigated by using cyclic voltammetry (CV) and differential pulse voltammetry (DPV) techniques. The electrochemical oxidation of GEM was an irreversible process which exhibited adsorption-diffusion controlled process behavior in Britton-Robinson (BR) buffer over the entire pH range of values from 2 to 9. The adsorptive stripping response was evaluated as a function of some variables such as pH, type of surfactant, scan rate and accumulation time. The anodic peak current varied linearly over the range from 8.0 × 10^-7 to 2.8 × 10^-5M. The limits of detection and quantification were 7.32 × 10^-8 M and 2.44 × 10^-7 M, respectively. The relative standard deviations and the percentage recoveries were found in the following ranges: 0.58-1.35% and 99.37-101.76%, respectively.
Keywords
Gemifloxacin; Gold Nanoparticles; Voltammetry; Tween 80; Urine


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