Electroanalytical Determination of Gemifloxacin Mesylate in Bulk, Tablets and Human Urine Using Gold Nanoparticles Modified Carbon Paste Electrode

Document Type: Research Paper

Authors

1 National Organization for Drug Control and Research (NODCAR)

2 National Organization for Drug Control and Research

3 Analytical Chemistry Department, Faculty of Pharmacy, Cairo University

Abstract

A simple, precise, inexpensive and sensitive voltammetric method has been developed for the determination of gemifloxacin mesylate (GEM) in the presence of tween 80 in the bulk, farmaceutical dosage forms and human urine at gold nanoparticles modified carbon paste electrode (GNCPE). The electrochemical behavior of GEM has been investigated by using cyclic voltammetry (CV) and differential pulse voltammetry (DPV) techniques. The electrochemical oxidation of GEM was an irreversible process which exhibited adsorption-diffusion controlled process behavior in Britton-Robinson (BR) buffer over the entire pH range of values from 2 to 9. The adsorptive stripping response was evaluated as a function of some variables such as pH, type of surfactant, scan rate and accumulation time. The anodic peak current varied linearly over the range from 8.0 × 10-7 to 2.8 × 10-5 M. The limits of detection and quantification were 7.32 × 10-8 M and 2.44 × 10-7 M, respectively. The relative standard deviations and the percentage recoveries were found in the following ranges: 0.58-1.35% and 99.37-101.76%, respectively.

Keywords

References

[1] M.N. Lowe, H.M. Lamb, Drugs 59 (2000) 1137.
[2] A. Marchese, E.A. Debbia, G.C. Schito, J. Antimicrob. Chemother. 46 (2000) 11.
[3] E. Doyle, S.E. Fowles, D.F. McDonnell, R. McCarthy, S.A. White, J. Chromatogr. B 746 (2000) 191.
[4] B.M. Al-Hadiya, A.A. Khady, G.A. Mostafa, Talanta 83 (2010) 110-116.
[5] N. Sultana, S. Shamim, M. Akhtar, S. Gul, M.S. Arayne, Quim Nova 33 (2010) 1590.
[6] A.R. Rote, S.P. Pingle, J. Chromatogr. B 877 (2009) 3719.
[7] N. Sultana, M.S. Arayne, S. Shamim, A. Naz, J. Chinese Chem. Soc. 58 (2011) 629.
[8] S. Shamim, N. Sultana, M.S. Arayne, M. Akhtar, S. Gul, Int. Res. J. Pharm. Pharmacol. 2 (2012) 245.
[9] M. Gumustas, S.A. Ozkan, Turk. J. Pharm. Sci. 9 (2012) 161.
[10] Z.M. Turabi, O.A. Khatatbeh, J. Pharma Res. 2 (2013) 8.
[11] A.K. Bera, A.K. De, B. Pal, Int. J. Pharm.Tech. Res. 6 (2014) 1011.
[12] N.A. Abdallah, J. Chromatogr. Separation Techniq. 5 (2014) 1.
[13] R.I. EL-Bagary, N.F. Abo-talib, M.B. Nour. Eldin, J. Chem. Pharm. Res. 3 (2011) 562.
[14] M.V. Krishna, D.G. Sankar, E-J. Chem. 5 (2008) 493.
[15] S. Ganapathy, G.V.H. Raju, D.G. Sankar, P.Y. Naidu, Asian J. Chem. 21 (2009) 6508.
[16] S. Dey, Y.V. Reddy, B. Krishna, S.K. Sahoo, P.N. Murthy, D. Kumar, J. Alam, M. Ghosh, Int. J. Chem. Anal. Sci. 1 (2010) 130.
[17] D. Jyothirmayee, G.S.S. Babu, G.D. Rao, Asian J. Chem. 22 (2010) 1634.
[18] M.V. Krishna, D.G. Sankar, E-J. Chem. 5 (2008) 515.
[19] S.S. Panda, B.V.V.R. Kumar, K.S. Rao, V.R. Kumar, D. Patanaik, Asian J. Biochem. Pharm. Res. 3 (2011) 442.
[20] S.B. Wankhede, A.M. Mahajan, S.S. Chitlange, Der Pharma Chemica 3 (2011) 269.
[21] D.C. Charan, S. Satyabrata, Int. J. Pharm.Tech. Res. 3 (2011) 133.
[22] S.A.M. Ebraheem, A.A. Elbashira, H.Y. Aboul-Enein, Acta Pharm. Sin. B 1 (2011) 248.
[23] K. Hajera, Int. J. Res. Pharm. Biomed. Sci. 3 (2012) 90.
[24] R. El-Sheikh, A.S. Amin, A.A. Gouda, A.G. Youssef, Pharm. Anal. Acta 4 (2013) 1.
[25] S.S.U. Hassan, U. Hayat, I. Tariq, I. Ahmad, M.M. Hayat, M. Uzair, M.T. Ansari, Pak. J. Pharm. Sci. 27 (2014) 1171.
[26] S.I. Cho, K.N. Lee, Y.K. Kim, J. Jang, D.S. Chung, Electrophoresis 23 (2002) 972.
[27] S.I. Cho, J. Shim, M.S. Kim, Y.K. Kim, D.S. Chung, J. Chromatogr. A 1055 (2004) 241.
[28] A.A. Elbashir, B. Saad, A.S.M. Ali, K.M.M. Al-Azzam, H.Y. Aboul-Enein, J. Liq. Chromatogr. Relat. Technol. 31 (2008) 1465.
[29] S.E.K. Tekkeli, A. Onal, J. Fluoresc. 21 (2011) 1001.
[30] B.A. Moussa, M.A. Mahrouse, M.A. Hassan, M.G. Fawzy, Acta Pharm. 64 (2014) 15.
[31] R. Jain, J.A. Rather, Colloids Surf. B 83 (2011) 340.
[32] A.E. Radi, A. Khafagy, A. El-shobaky, H. El-mezayen, J. Pharm. Anal. 3 (2013) 132.
[33] M.A. Elshal, A.K. Attia, S.A. Abdulla, J. Adv. Sci. Res. 4 (2013) 25.
[34] N.F. Abo-talib, Anal. Bioanal. Electrochem. 5 (2013) 74.
[35] H. Zhao, Y. Chen, J. Tian, H. Yu, X. Quan, J. Electrochem. Soc. 159 (2012) J231.
[36] N.F. Atta, A. Galal, F.M. Abu-Attia, S.M. Azab, J. Electrochem. Soc. 157 (2010) F116.
[37] T. Madrakian, E. Haghshenas, A. Afkhami, Sens. Actuat. B 193 (2014) 451.
[38] B.J. Sanghavi, P.K. Kalambate, S.P. Karna, A.K. Srivastava, Talanta 120 (2014) 1.
[39] C. Wang, R. Yuan, Y. Chai, S. Chen, F. Hu, M. Zhang, Anal. Chim. Acta 741 (2012)15.
[40] S.M. Ghoreishi, M. Behpour, N. Jafari, A. Khoobi, Anal. Lett. 46 (2013) 299.
[41] N.F. Atta, A. Galal, S.M. Azab, Int. J. Electrochem. Sci. 6 (2011) 5082.
[42] D.K. Gosser, Cyclic Voltammetry: Simulation and Analysis of Reaction Mechanism, VCH, New York, 1993, 43.
[43] E. Laviron, L. Roullier, C. Degrand, J. Electroanal. Chem. 112 (1980) 11.
[44] M.Y. Lachapelle, G. Drouin, Genetica 139 (2010) 199.
[45] J. Premkumar, S.B. Khoo, J. Electroanal. Chem. 576 (2005) 105.
[46] C.R. Raj, F. Kitamura, T. Ohsaka, Analyst 9 (2002) 1155.

Analytical and Bioanalytical Chemistry Research

Volume 1, Issue 2
Autumn 2014
Pages 128-138

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