Gold Nanoparticles/Cysteic Acid Modified Electrode for Simultaneous Electrochemical Determination of Tramadol and Paracetamol

Document Type : Research Paper

Authors

1 Department of Chemistry, Razi University, Kermanshah, Iran

2 Department of Chemistry, Razi University, Kermanshah-Iran

Abstract

Electrochemical deposition of gold nanoparticles (AuNPs) and l-Cysteine on glassy carbon electrode was carried out to prepare a modified electrode. The fabricated sensor showed good sensitivity and selectivity for simultaneous determination of paracetamol (PAR) and tramadol (TRA) by square wave voltammetry. Linear ranges of 0.10 - 10.7 μM (PAR) and 0.50 - 63.6 μM (TRA) were obtained with detection limits of 0.03 and 0.17 μM, respectively. The relative standard deviation (RSD %) for simultaneous determinations of PAR (10 µM) and TRA (30 µM) was calculated to be 3.11 and 3.30%, respectively (5 replicate determinations). Moreover, when 3 different electrodes were used, RSD% for PAR and TRA was 3.92 and 4.02%, respectively. The proposed electrode was used successfully in the simultaneous determination of the drugs in spiked human plasma samples.The calculated recoveries for PAR and TRA in blood serum were found to be in the rage 99.5-102 %, with RSD% 0.71 – 1.9%.

Keywords


[1]       R. Raffa, J. Clin. Pharm. Ther. 26 (2001) 257.
[2]       M. Toral, J. Rivas, M. Saldias, C. Soto, S. Orellana, J. Chil. Chem. Soc. 53 (2008) 1543.
[3]       T. Belal, T. Awad, C.R. Clark, J. Chromatogr. Sci. 47 (2009) 849.
[4]       R. Chandra, K.D. Sharma, Int. J. Chromatogr. Sci. 3 (2013) 31.
[5]      
G. Saccomanni, S. Del Carlo, M. Giorgi, C. Manera, A. Saba, M. Macchia, J. Pharm. Biomed. Anal. 53 (2010) 194.
[6]       G.M. Hadad, R.A. Salam, R.M. Soliman, M.K. Mesbah, Talanta 101 (2012) 38.
[7]       K.B. Vinay, H.D. Revenasiddappa, S.A. Abdulrahman, Turk. J. Pharmaceut. Sci. 10 (2013) 57.
[8]       Sirajuddin, A.R. Khaskheli, A. Shah, M.I. Bhanger, A. Niaz, S. Mahesar, Spectrochimica Acta Part A: Mol. Biomol. Spectroscopy 68 (2007) 747.
[9]       E.M. Garrido, J.M. Garrido, F. Borges, C. Delerue-Matos, J. Pharm. Biomed. Anal. 32 (2003) 975.
[10]    R.M. de Carvalho, R.S. Freire, S. Rath, L.T. Kubota, J. Pharm. Biomed. Anal. 34 (2004) 871.
[11]    D. Sun, H. Zhang, Microchim. Acta 158 (2007) 131.
[12]    B. Habibi, M. Jahanbakhshi, M.H. Pournaghi-Azar, Anal. Biochem. 411 (2011) 167.
[13]    A.A. Ensafi, H. Karimi-Maleh, S. Mallakpour, M. Hatami, SensorActuat B: Chemical 155 (2011) 464.
[14]    S.A. Kumar, C.F. Tang, S.M. Chen, Talanta 76 (2008) 997.
[15]    W.-Y. Su, S.-H. Cheng, Electroanalysis 22 (2010) 707.
[16]    M.H. Pournaghi-Azar, A. Saadatirad, Simultaneous Determination of Paracetamol, Electroanalysis 22 (2010) 1592.
[17]    F. Ghorbani-Bidkorbeh, S. Shahrokhian, A. Mohammadi, R. Dinarvand, Electrochim. Acta 55 (2010) 2752.
 
 
[18]    M. Doulache, B. Saidat, M. Trari, Russ. J. Electrochem. 53 (2017) 461.
[19]    A. Rahi, K. Karimian, H. Heli, Anal. Biochem. 497 (2016) 39.
[20]    F. Zhang, S. Gu, Y. Ding, L. Li, X. Liu, Bioelectrochemistry 89 (2013) 42.
[21]    C. Wang, Z. Wang, J. Guan, X. Hu, Sensors 6 (2006) 1139.
[22]    H.Y. Jia, Y. Liu, X.J. Zhang, L. Han, L.B. Du, Q. Tian, et al., JACS 131 (2009) 40.
[23]    M.C. Daniel, D. Astruc, Chem. Rev. 104 (2004) 293.
[24]    S. Guo, E. Wang, Anal. Chim. Acta 598 (2007) 181.
[25]    P.S. Dorraji, F. Jalali, SensorActuat B: Chemical 200 (2014) 251.
[26]    S. Fei, J. Chen, S. Yao, G. Deng, D. He, Y. Kuang, Anal. Biochem. 339 (2005) 29.
[27]    H. Li, T. Li, E. Wang, Talanta 42 (1995) 885.
[28]    N. Spataru, B.V. Sarada, E. Popa, D.A. Tryk, A. Fujishima, Anal. Chem. 73 (2001) 514.
[29]    J.  Zagal,  C. Fierro,  R.  Rozas,  J. Electroanal.  Chem.  
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
Interfacial Electrochem. 119 (1981) 403.
[30]    E.G. Araújo, A. Jhones dos Santos, D.R. da Silva, R. Salazar, C.A. Martínez-Huitle, Electroanalysis 26 (2014) 748.
[31]    A.H. Shah, A. Shah, U.A. Rana, S.U.-D. Khan, H. Hussain, S.B. Khan, et al., Electroanalysis 26 (2014) 2292.
[32]    S.J. Malode, S.T. Nandibewoor, Asian J. Pharm. Clin. Res. 6 (2013) 71.
[33]    D.J. Miner, J.R. Rice, R.M. Riggin, P.T. Kissinger, Anal. Chem. 53 (1981) 2258.
[34]    R.N. Goyal, V.K. Gupta, M. Oyama, N. Bachheti, Electrochem. Commun. 7 (2005) 803.
[35]    A. Afkhami, H. Khoshsafar, H. Bagheri, T. Madrakian, Anal. Chim. Acta 831 (2014) 50.
[36]    A. Bard, L. Faulkner, Electrochemical Methods: Fundamentals and Applications, 2nd edn, 2001.
[37]    S. Chitravathi, N. Munichandraiah, J. Electroanal. Chem. 764 (2016) 93.