Terbium Sensitized Chemiluminescence Method for the Determination of Rabeprazole -Application to Pharmaceutical Analysis and Dissolution Studies

Document Type : Research Paper

Authors

Department of Analytical Chemistry, Faculty of Chemistry, University of Tabriz, Tabriz 5166614671, Iran

Abstract

A simple and sensitive chemiluminescence-based method was established for the determination of rabeprazole.The proposed method was based on the enhancing effect of rabeprazole on Ce(IV)-Na2SO3 -Tb(III) chemiluminescence reaction. A possible mechanism was discussed for chemiluminescence system by studying UV-Vis, fluorescence and chemiluminescence spectra. The effects of various chemical parameters were investigated and optimized. Under the optimum conditions, the enhanced chemiluminescence intensity was directly proportional to the concentration of rabeprazole in the range of 0.015-0.2 µg ml-1, with a detection limit of 6 ng ml-1. The proposed method was applied to the analysis of pharmaceutical formulations and human plasma samples and to the dissolution study of rabeprazole tablets with satisfactory results. The results indicated that more than 95% of the labeled amount of rabeprazole was dissolved over 30 min in the basic medium, while only 10% of rabeprazole was released in acidic medium.

Keywords

References

[1] M.P. Williams, R.E. Pounder, Alimen. Pharm. Ther. 13 (1999) 3.
[2] S. Shi, U. Klotz, Europ. J. Clin. Pharm. 64 (2008) 935.
[3] Guidance for Industry dissolution testing of immediate release solid oral dosage forms,
US FDA, 1997. http://www.fda.gov/cder/guidance/1713bp1.pdf
[4] H.M. Mohamed, Spectrochim. Acta A 136 (2015) 1308.
[5] S.S. Sabnis, N.D. Dhavale, V.Y. Jadhav, S.V. Gandhi, Spectrochim. Acta A 69 (2008) 849.
[6] V. Asfak, D. Mrinalini, B. Leena, G. Rahul, Chromatographia 66 (2007) 941.
[7] R. Nageswara Rao, A. Narasa raju, D. Nagaraju, Talanta 70 (2006) 805.
[8] F. Ibrahim, M.E.K. Wahba, j. Fluoresc 24 (2014) 1137.
[9] T. Uno, N. Yasui-Furukori, M. Shimizu, K. Sugawara, T. Tateishi, J. Chromatogr. B 824 (2005) 238.
[10] B. Patel, B. Suhagia, M. Patel, J. Patel, Chromatographia 65 (2007) 743.
[11] N.V.S. Ramakrishna, K.N. Vishwottam, S. Wishu, M. Koteshwara, S.S. Kumar, J. Chromatogr. B 816 (2005) 209.
[12] M. Miura, H. Tada, S. Satoh, T. Habuchi, T. Suzuki, J. Pharma. Biomed. Anal. 41 (2006) 565.
[13] C. Lua, Y. Jiaa, Y. Songa, X. Lia, Y. Suna, J. Zhaoa, S. Wanga, L. Shic, A. Wena, L. Dingb, J. Chromatogr. B 988 ( 2015) 75.
[14] T. Hishinuma, K. Suzuki, H. Yamaguchi, H. Yamagishi, T. Koike, S. Ohara, T. Shimosegawa, N. Mano, J. Goto, J. Chromatogr. B 870 (2008) 38.
[15] C.V. Garcia, C.S. Paim, M. Steppe, E.E.S. Schapoval, J. Pharm. Biomed. Anal. 41 (2006) 833.
[16] A.M. García-Campaña, W.R.G. Baeyens, Chemiluminescence in analytical chemistry. New York: Marcel Dekker, 2001.
[17] J.A. Ocaña, F.J. Barragán, M. Callejón, F. De la Rosa, Microchim. Acta 144 (2004) 207.
[18] D. Li, J. Du, J. Lu, Microchim. Acta 161 (2008) 169.
[19] F. Zhao, Y. Qi, W. Xiong, Korean Chem. Soc. 33 (2012) 204.
[20] J. Du, D. Li, J. Lu, Luminescence 25 (2010) 76.
[21] M. Kaczmarek, J. Luminescence 162 (2015) 31.
[22] K. Takeuchi, T. Ibusuki, Anal. Chim. Acta 174 (1985) 359.
[23] L. Capitán-Vallvey, M. Valencia Mirón, R. Acosta Acosta, Talanta 51 (2000) 1155.
[24] S. Zhang, Y. Zhuang, H. Ju, Anal. Let. 37 (1) (2004) 143.
[25] Z. Xie, X. Ouyang, L. Guo, X. Lin, G. Chen, Z. Xie, X. Ouyang, L. Guo, X. Lin, G. Chen, Luminescence 20 (2005) 226.
[26] L.H. Nie, H.C. Zhao, X. Wang, L. Yi, Y. Lu, L.P. Jin, H.M. Ma, Anal. Bioanal. Chem. 374 (2002) 1187.
[27] J. Ocaña, M. Callejón, F. Barragán, F. De la Rosa, Anal. Chim. Acta 482 (2003) 105.
[28] N. Lian, H. Zhao, C. Sun, S. Chen, Y. Lu, L. Jin, Microchem. J. 74 (2003) 223.
[29] T. Hallaj, M. Amjadi, J.L. Manzoori, M.H. Sorouraddin, J. Anal. Chem. 70 (2015) 166.
[30] J. González, M. Payán, R. Torres, M. Mochón and M. López, J. Sep. Sci. 37 (2014) 2738.
[31] X. Wang, H. Zhaoa, L. Nie, L. Jin, Z. Zhang, Anal. Chim. Acta 445 (2001) 169.
[32] J.L. Adcock, P.S. Francis and N.W. Barnett, Anal. Chim. Acta 652 (2009) 303.
[33] Y. Huang, C. Zhang, X. Zhang and Z. Zhang, Anal. Chim. Acta 391 (1999) 95.
[34] H.L. Greenhaus, A.M. Feibush and L. Gordon, Anal. Chem. 29 (1957) 1531.
[35] H. Sun, L. Li, X. Chen, Anal. Chim. Acta 576 (2006) 192.

Files

Share

How to cite

Statistics