TY - JOUR ID - 49070 TI - Electrosynthesis of Clozapine Drug Derivative via an EC Electrochemical Mechanism JO - Analytical and Bioanalytical Chemistry Research JA - ABCR LA - en SN - AU - Tammari, Esmail AU - Nezhadali, Azizollah AU - Lotfi, Shahram AU - Mohammadizadeh, Mohammad Reza AD - Department of Chemistry, Faculty of Sciences, Persian Gulf University, Bushehr 75169, Iran AD - Department of chemistry, Payame Noor University (PNU),19395-4697 Tehran, I.R. of Iran Y1 - 2017 PY - 2017 VL - 4 IS - 2 SP - 319 EP - 328 KW - Clozapine (CLZ) KW - Electrosynthesis KW - Dibenzodiazepin KW - Cyclic Voltammetry KW - 2-Thiobarbituric acid (TBA) DO - 10.22036/abcr.2017.82592.1142 N2 - The fact that oxidation, as one of the main routes of phase I metabolism of drugs, follows by conjugation reactions, and also formation of nitrenium ion as one of the clozapine oxidation products, directed us to investigate the oxidation of clozapine (CLZ) in the presence of nucleophile. The oxidation of clozapine (CLZ) has been studied on a glassy carbon electrode in the absence and presence of 2-thiobarbituric acid (TBA) as nucleophile in aqueous medium by means of cyclic voltammetry and on the graphite rods in controlled-potential coulometry. Cyclic voltammetry studies were realized for CLZ in the pHs 1.0 to 8.0. Results indicate that the electrochemical behavior of CLZ depends on the pH. Based on the obtained electrochemical results, an ECE mechanism was proposed to explain the electrochemical oxidation of CLZ. The results revealed that oxidized CLZ participates in Michael type addition reaction with TBA and via an EC mechanism converts to the corresponding new dibenzodiazepin derivatives. The product has been characterized by IR, 1H NMR, 13C NMR and MS. UR - https://www.analchemres.org/article_49070.html L1 - https://www.analchemres.org/article_49070_facb1b00b74467ff28516b897e0b7dcd.pdf ER -