Document Type : Research Paper
Faculty of Chemistry, Razi University, Kermanshah, Iran
Faculty of Chemistry, Razi University, Kermanshah, Iran. Nanobiotechnology Department, Faculty of Innovative Science and Technology, Razi University, Kermanshah, Iran. Nano Drug Delivery Research Center, Faculty of Pharmacy, Kermanshah University of Medical Sciences, Kermanshah, Iran
Nano Drug Delivery Research Center, Faculty of Pharmacy, Kermanshah University of Medical Sciences, Kermanshah, Iran
In this article, polycaprolactone (PCL) polymer nanofibers has been used in the presence of curcumin (Cur) to control the corrosion rate of temporary magnesium (alloy AZ31) implants. PCL, PCL-Cur, and sodium alginate (SA)-polyvinyl alcohol (PVA)/PCL-Cur polymer coating were produced. The mentioned nanofibers were produced using a simple and cost-effective electrospinning technique. We used different techniques to examine the properties of the produced fibers, and it was demonstrated that the hydrophobic produced nanofibers with contact angle of 135.2 degrees have continuous strands and a diameter of 171.57 nm. The presence of Cur inside PCL nanofiber not only did not have any effect on the PCL nanofiber morphology, but also it increased adhesion of the coating, and 74.59% of Cur was released after 7 days. To investigate the effects of different polymeric coatings on the surface of Mg metal in the simulated body fluid (SBF), SEM, weight measurement tests, pH measurement, Polarization, and Electrochemical Impedance Spectroscopy (EIS) has been used. During the study period there was no degradation in any part of the PCL-Cur hydrophobic polymer coating. For this coating, the percentage of weight loss, pH value, corrosion potential (Ecorr) and corrosion rate (CR) were 0.19%, 8.39, -1.388 V and 0.198 mm/y, respectively, where these values indicate the significant decrease of corrosion rate while using PCL-Cur coating.