Curcumin Nanoparticle/AgNPs/Multiwalled Carbon Nanotube Nanocomposite as a Novel Electrochemical Sensor for Electrocatalytic Simultaneous Determination of Adrenaline and Tryptophan

Document Type : Research Paper


Faculty of Nano and Bio Science and Technology, Persian Gulf University, Bushehr, 75169, Iran


A novel highly sensitive and selective electrochemical sensor with low limit of detection and wide linear ranges for elecotrooxidation of adrenaline (Adr) and tryptophan (Trp) were utilized by immobilization of curcumin nanoparticles, AgNPs on MWCNTs on glassy carbon electrode. The SEM and XRD analysis were applied for characterization of fabricated sensor surface. The diameter of synthesized nanoparticles was obtained 39 to 64 nanometers using SEM analysis. The CV peak currents of Adr and Trp were linear in range 1.0-1150 µmol L-1 and 0.5-1200 µmol L-1 respectively. The detection limit was found 0.058 µmol L-1 and 0.032 µmol L-1, for Adr and Trp, respectively. The fabricated nanocomposite was successfully employed to determine Adr in an adrenaline injection solution as well as Adr and Trp in a human urine sample. The calculated recovery values confirmed that electrochemical was appropriate for the precise and accurate simultaneous determination of target Adr and Trp in complex mixtures with recovery in the range of 98–103%.