Fast and Sensitive Determination of Acetic Anhydride in the Air Using Hollow Fiber Method

Document Type : Research Paper


1 Occupational Health, Student Research Committee, Hamadan University of Medical Sciences, Hamadan, Iran

2 Center of Excellence for Occupational Health, Research Center for Health Sciences, School of Public Health, Hamadan University of Medical Sciences, Hamadan, Iran

3 Department of Biostatistics, School of Public Health and Research Center for Health Sciences, Hamadan University of Medical Sciences, Hamadan, Iran


This study aimed to introduce a new method based on Hollow Fiber in order to determination of acetic anhydride (AA) in the air. Hydroxylamine hydrochloride and sodium hydroxide (1:1), were used as extraction solvent. This method was studied in the laboratory under various conditions. In order to make different concentrations of AA in the air, a standard glass chamber was used. The optimization of the sampling parameters and breakthrough volume was performed using the response surface method (RSM) and Design-Expert software (v.11.0). The results of the study indicated that the optimum sampling rate was 10 mL/min. The repeatability estimates of the proposed method including intra and inter-day were in the confine of 0.079–0.11 and 0.081–0.14, respectively. The limit of detection (LOD) and limit of quantitation (LOQ) of the examined analytes were 0.003 and 0.009 ng/mL, respectively. The storage time for the HF sampling method was seven days at laboratory temperature. The overall conclusion is that the HF sampling method showed a great sensitivity for the sampling of AA in the air. It could be assumed that HF sampling method is a fast, reliable and sensitive method and had a proper performance in the sampling of AA, compared to the National Institute for Occupational Safety and Health (NIOSH)- 3506 method.


[1]       J.-Y. Lee, Y. Yamamoto, R. Oe, S.-Y. Son, Hitoshi Wakabayashi, Y. Tochihara, Ergonomics 57 (2014) 8.
[2]       Health. Division of Physical Sciences, NIOSH, Manual of Analytical Methods. US Department of Health and Human Services, Public Health Service, Centers, 1994
[3]       W.M. Diggle, J.C. Gage, Analyst 78 (1953) 929.
[4]       C. Prandi, F. Terraneo, Anal. Chem. 50 (1978) 14.
[5]       E. Taheri, A. Bahrami, F. Ghorbanishahna, M. Farhadian, Environ. Monit. Assess. 190 (2018) 8.
[6]       Z. Zhang, M.J. Yang, Janusz J. Anal. Chem. Pawliszyn 66 (1994) 17.
[7]       A. Sarafraz-Yazdi, A.H. Amiri, Z. Es’haghi, J. Chemosphere 71 (2008) 4.
[8]       M.R. Payán, M.A.B. López, R. Fernández-Torres, M.V. Navarro, M.C. Mochón, J. Talanta 79 (2009) 3.
[9]       X. Ma, M. Huang, Z. Li, J. Wu, J. Hazard. Mater. 194 (2011).
[10]     A.      Sarafraz-Yazdi,     A.H.   Amiri,   Z.   Es’haghi,
Chemosphere 71 (2008) 4.
[11]    E. Psillakis, N. Kalogerakis, TrAC Trends in Anal. Chem. 22 (2003) 9.
[12]    S. Dadfarnia, A. Mohammad Haji Shabani, Anal. Chim. Acta 658 (2010) 2.
[13]    F. Ghamari, A. Bahrami, Y. Yamini, F. GhorbaniShahna, A. Moghimbeigi, Anal. Chem. Insights. 11 (2016).
[14]    Z. Es’haghi, M. Ebrahimi, M. Saeid, A. Hosseini, J. Chromatogr. 1218 (2011) 21.
[15]    X. Ma, Minghua Huang, Z. Li, J. Wu, J. Hazardous Mater. 194 (2011).
[16]    J. Luis González, A. Pell, M. López-Mesas, Manuel %J Science of The Total Environment Valiente, 630 (2018).
[17]    A. Bahrami, E. Partovi, A. AfKhami, F. Ghorbani Shahna, F. Ghamari, M. Farhadian, Ann. Work Exposures Health (2019).
[18]    A.D. Smolenkov, I.A. Rodin, O.A. Shpigun, J. Anal. Chem. 67 (2012) 2.
[19]    S.S. Moghaddam, M.R.A. Moghaddam, M. Arami, J. Hazard. Mater. 175 (2010) 1-3.
[20]    I.A.W. Tan, A.L. Ahmad, B.H. Hameed, J. Hazard. Mater. 153 (2008) 1.
[21]    A. Witek-Krowiak, K. Chojnacka, D. Podstawczyk, A. Dawiec, Karol %J Bioresource Technology Pokomeda 160 (2014).
[22]    A.I. Khuri, J.A. Cornell, Response Surfaces: Designs and Analyses, Routledge, 2018.
[23]    André I Khuri,Siuli %J Wiley Interdisciplinary Reviews: Computational Statistics Mukhopadhyay, 2 (2010) 2.
[24]    N.G. Yasri, H. Seddik, M.A. Mosallb, Arabian J. Chem. 8 (2015) 4.
[25]    C.T. Yan, H.Y. Chien, J. Chromatogr. A 1246 (2012).